FOXO4-DRI
FOXO4-DRI research peptide. Third-party Certificates of Analysis are published for tested products and batches. Fast UK dispatch. For laboratory research use only.
Available sizes: 10 mg
A Senolytic Research Peptide Studied in Cellular Senescence and FOXO4-p53 Signalling
FOXO4-DRI is an experimental senolytic peptide studied for its interaction with the FOXO4-p53 signalling pathway, a cellular mechanism associated with the survival of senescent cells.
Cellular senescence occurs when cells permanently stop dividing but remain metabolically active. These cells can accumulate within tissues over time, making the mechanisms controlling their survival and removal an important area of ageing and longevity research.
FOXO4-DRI has been developed as a research tool designed to interfere with the interaction between FOXO4 and p53. Preclinical studies have investigated whether disrupting this interaction can encourage apoptotic signalling in senescent cells while providing insight into how senescent-cell accumulation influences tissue function.
Why FOXO4-DRI Is Studied
Cellular Senescence Research: Used to investigate the mechanisms that allow senescent cells to persist within ageing tissues.
FOXO4-p53 Interaction: Specifically studied for its ability to disrupt signalling between FOXO4 and the tumour-suppressor protein p53.
Senolytic Mechanisms: Investigated as an experimental approach to selectively influence the survival of senescent cells.
Age-Related Tissue Models: Used in preclinical research examining how senescent-cell accumulation contributes to declining tissue homeostasis.
Scientific Research Context
FOXO4 is a transcription factor involved in cellular stress responses, survival, and homeostasis. In senescent cells, interaction between FOXO4 and p53 has been identified as one mechanism contributing to continued cellular survival.
FOXO4-DRI is a modified peptide designed to compete with this interaction. Experimental studies have shown that disrupting FOXO4-p53 binding can alter the localisation and activity of p53 and promote apoptotic signalling in senescent cellular models.
This mechanism has made FOXO4-DRI an important experimental compound in the developing field of senolytic and cellular ageing research.
Common Research Focus Areas
Cellular senescence
FOXO4 and p53 signalling
Senescent-cell apoptosis
Age-related cellular dysfunction
Senolytic research models
Related Peptides
FOXO4-DRI is studied within the broader field of cellular ageing, senescence, and longevity signalling.
Rather than directly stimulating tissue growth, this area of research focuses on understanding how ageing cells persist, communicate with surrounding tissue, and influence the maintenance of normal cellular environments.
Documentation and verification
Certificates of Analysis are published for tested products and batches. A certificate is a batch-specific record: it reports what was measured, by which method, on a stated date, against a batch identifier. It is evidence about the sample analysed at the time of analysis, and it is silent on attributes it does not list and on what has happened to the material since.
The batch number is the field that connects the document to a physical vial. Where the identifier on a vial does not appear on a certificate, the certificate does not describe that vial, however thorough the analysis behind it was. Batch records can be searched directly, and the guides below explain what each field establishes and what it does not.
- Verify a batchSearch a batch number for the certificate records published against it.
- How to read a certificate of analysisWhat each field reports, and the limits of what a certificate can establish.
- Certificate, specification and safety data sheetThree documents that answer three different questions.
- Storage and handlingWhat defined storage conditions mean, and why cold slows degradation.
- Batch numbers and traceabilityHow an identifier ties material to the analysis describing it.
Supplied for laboratory research use only. Not for human or veterinary use.