Scientific Reference
LL-37 (Human Cathelicidin)
Evidence profile: Preclinical, with limited uncontrolled human reports
LL-37 is the only known human cathelicidin antimicrobial peptide, consisting of 37 amino acids and derived from the precursor protein hCAP18. It plays a critical role in innate immunity, exhibiting broad-spectrum antimicrobial activity against bacteria, viruses, and fungi while also modulating inflammatory responses and promoting tissue repair. It is most commonly studied in topical applications for wound healing, where it provides both antimicrobial protection and regenerative support. Clinical and experimental data show significant improvements in chronic wound healing, though systemic use remains less well characterized.
Mechanism of Action
LL-37 disrupts microbial membranes through its cationic amphipathic structure, leading to rapid pathogen destruction. It also modulates immune signaling pathways, reduces excessive inflammation, and promotes tissue repair via enhanced keratinocyte migration, angiogenesis, and extracellular matrix remodeling. Topical delivery enables direct action at wound sites with minimal systemic exposure.
Molecular Information
- Type: Antimicrobial peptide (cathelicidin)
- Length: 37 amino acids
- Molecular weight: 4493 g/mol
- Molecular formula: C205H340N60O53
- CAS: 154947-66-7