Scientific Reference
5-Amino-1MQ
Evidence profile: Predominantly preclinical
5-Amino-1MQ is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), developed for metabolic and longevity-focused research. By targeting a key regulatory enzyme involved in NAD+ metabolism, it has been investigated for its ability to enhance cellular energy production and mitochondrial efficiency. The compound is primarily explored in the context of metabolic health, body composition, and age-related cellular decline. Preclinical research suggests that modulation of NNMT activity may influence adiposity, insulin sensitivity, and mitochondrial biogenesis, making it of interest in both obesity and longevity research domains.
Mechanism of Action
5-Amino-1MQ inhibits the NNMT enzyme, reducing the methylation of nicotinamide and preventing NAD+ depletion. This results in elevated intracellular NAD+ levels, which support mitochondrial function, sirtuin activation, and metabolic regulation. The downstream effects include improved energy metabolism, enhanced cellular repair mechanisms, and modulation of adipocyte function.
Molecular Information
- Type: Small molecule NNMT inhibitor
- Molecular weight: 159.21 g/mol
- Molecular formula: C10H11N2+